Scientist I, Radiopharmacology

POSITION TITLE: Scientist I, Radiopharmacology

REPORTING LOCATION: Rockville, MD

REPORTS TO: Head of Radiopharmacology

PRIMARY OBJECTIVE: Join our team to advance radiochemistry and cancer research, supporting the launch of our in vivo radio conjugate program. Support the operations and commercial teams for in vivo study planning and execution utilizing radio conjugates for testing in Champions extensive PDX Tumorbank in preclinical mouse pharmacology studies.

DUTIES, RESPONSIBILITIES AND PRODUCTIVITY EXPECTATIONS:

• Design and execute radiolabeling reactions using a range of isotopes, including Lu-177, Ac-225, In-111, Zr-89, At-211, I-131, and Pb-212.
• Perform conjugation reactions between bifunctional chelators and peptides or proteins.
• Develop and optimize radiochemical synthesis protocols for both diagnostic and therapeutic applications.
• Conduct quality control and stability testing of radiolabeled
• Analyze experimental data, interpret results, and communicate findings to cross-functional teams.
• Support preclinical research studies, including biodistribution, pharmacokinetics, and dosimetry assessments.
• Prepare, review, and ensure compliance of study protocols and technical reports
• Train and mentor junior staff in radiochemistry techniques, radiation safety, and handling of radioactive materials.
• Maintain accurate laboratory records
• Stay current with advancements in radiochemistry, nuclear medicine, and isotope production technologies.
• Assist in the evaluation and implementation of new equipment, automation systems, and analytical tools.
• Other duties may be assigned verbally at any time.

KNOWLEDGE, SKILLS, AND ABILITIES:

• Expertise in radiochemistry, radiobiology, molecular imaging, and therapeutic radionuclide production and handling.
• Expertise in chromatography techniques such as thin-layer chromatography (TLC), column chromatography, high-performance liquid chromatography (HPLC).
• Expertise in conducting in vivo studies using radiolabeled compounds
• Experience with analysis and interpretation in vivo data of radioconjugate pharmaceuticals.

EDUCATION AND EXPERIENCE:

• PhD in a relevant field (e.g., radiochemistry, chemistry, biochemistry, pharmaceutical sciences).
• Expertise in radiochemistry, radiobiology, molecular imaging, and therapeutic radionuclide production.
• Experience with analysis and interpretation in vivo data of radioconjugates.
• Strong computer, organizational, and multitasking skills.
• Excellent communication skills.

PHYSICAL DEMANDS AND WORK ENVIRONMENT:

• Must be able to sit and use hands to finger, handle and feel.
• Must be able to lift and move packages weighing up to 50 pounds.
• Must be able to sit for long periods of time using a computer in a typical office environment in a multi-level facility.
• Some activities require repetitive motion and reaching, pulling, or pushing.
• In carrying out the duties of the job there will be frequent exposure to fumes and chemical hazards
• Duties performed routinely require exposure to blood, body fluid and tissue.

This description reflects management’s assignment of essential functions, it does not proscribe or restrict the tasks that may be assigned.  We celebrate diversity and are committed to creating an inclusive environment for all employees.